Once an exposure has occurred, the blood of the individual from whom exposure occurred should be tested for hepatitis B surface antigen (HBsAg) and antibody to human immunodeficiency virus (HIV antibody). Local laws regarding consent for testing source individuals should be followed. Testing of the source individual should be done at a location where appropriate pretest counseling is available; post-test counseling and referral for treatment should be provided.

	Hepatitis B Virus Post-exposure Management Treatment When Source is Found to Be:
Exposed Worker	HBsAg-positive	HBsAg-negative	Unknown or not tested
Unvaccinated	Initiate hepatitis B vaccine and Worker should receive a single dose of hepatitis B immune globulin (HBIG) as soon as possible and within 24 hours, if possible	Initiate hepatitis B vaccine.	Initiate hepatitis B vaccine
Previously Vaccinated	No treatment	No treatment	No treatment
Known Responder	Test exposed worker for anti-HBs: If adequate, no treatment If inadequate, hepatitis B vaccine booster dose	No treatment	No treatment
Known Nonresponder	Worker should receive 2 doses HBIG (give second dose 1 month after the first dose) or, Worker should receive 1 dose HBIG plus 1 dose hepatitis B vaccine.	No treatment	In known high-risk source, may treat worker as if source were HBsAg-positive
Response Unknown	Test exposed worker for anti-HBs: If inadequate, 1 dose HBIG plus hepatitis B vaccine booster dose. If adequate, no treatment	No treatment	Test exposed worker for anti-HBs: If inadequate, hepatitis B vaccine booster dose If adequate, no treatment