Douglass L. Jackson, DMD, MS, PhD
Douglass L. Jackson,
DMD, MS, PhD
Phone: (206) 221-5170
Email:jacksond@u.washington.edu
Mailing Address:
Oral Medicine
Box 356370
School of Dentistry
University of Washington
Seattle, WA 98195-6370
Background
Dr. Douglass Jackson received his dental degree from the University of Pittsburgh School of Dental Medicine. He has received advanced clinical training in anesthesiology at the University of Pittsburgh Medical Center. Dr. Jackson also has a Masters degree in the area of Clinical Research Design and Statistical Analysis from the University of Michigan's Graduate School of Public Health, and a PhD in Oral Biology with an emphasis in the areas of neuroscience and pharmacology from the University of Minnesota.
His clinical activities at the University of Washington School of Dentistry are limited to anesthesiology. Since joining the faculty in 1996, Dr. Jackson has established clinical anesthesia collaborations with the Departments of Dental Public Health Sciences (Dental Fears Research Clinic), Pediatric Dentistry, and Oral and Maxillofacial Surgery. Besides providing a variety of anxiety and pain control services to patients being treated in the School of Dentistry, he is also the Principal Investigator of the Department's Neuropharmacology Laboratory.
Dr. Jackson's primary research interest is the neurobiology of acute pain and inflammation. A multi-methodologic approach is utilized in the basic science research conducted by Dr. Jackson and his colleagues to evaluate the regulation of a select population of sensory neurons. The activation of the peripheral terminals of these neurons has been implicated in the development of hyperalgesia and the neurogenic component of inflammation that follows tissue injury. Current research conducted in Dr. Jackson's laboratory is evaluating the role of excitatory amino acid receptors and purinergic receptors in the development of hyperalgesia and neurogenic inflammation in peripheral tissues (e.g., tooth pulp, skin).
Recent Publications
Jackson DL, Graff CB, Richardson JD, Hargreaves KM Glutamate participates in the peripheral modulation of thermal hyperalgesia in rats. Eur J Pharmacol 1995 Sep 25;284(3):321-5 Department of Restorative Sciences, School of Dentistry, University of Minnesota, Minneapolis 55455, USA.
Jackson DL, Groves NK, Graff CB, Hargreaves KM. Glutamate Released into Peripheral Tissue During Inflammation Contributes to the Development of Thermal Hyperalgesia in Rats. Abs. Soc. Neurosci. 21: 1995.
Rothstein TJ, Swift JQ, Hargreaves KM, Jackson DL. Local Tissue Concentrations of iBradykinin Increase Following Tooth Extraction in Rats. J. Dent. Res. 75:137, 1996.
Moore PA, Finder RL, Jackson DL. Multidrug intravenous sedation: Determinants of the sedative dose of midazolam. Oral Surg. Oral Med. Oral Pathol. Oral Radiolo. Endod. 84:5-10, 1997.
Moore PA, Finder, RL, Jackson DL. Determinants of Midazolam Dose for Sedation Titration. J. Dent. Res. 76:32, 1997.
Jackson DL and Imthurn NI. Local Pretreatment with MK-801 attenuates carrageenan-induced inflammation of rat hindpaws. Abs. Soc. Neurosci. 24:1867, 1998.
Moore PA, Crout RJ, Jackson DL, Schneider LG, Graves RW, Bakos L. Tramadol Hydrochloride: Analgesic Efficacy Compared to Codeine, Aspirin with Codeine and Placebo in Dental Extraction Pain. J. Clin. Pharmacol. 38:554-560, 1998.
Kobayashi MR, Imthurn NI, Jackson DL. NMDA Modulation of Capsaicin-Evoked iCGRP Release from Dental Pulp. J. Dent. Res. 78:296, 1999.
Jackson DL and Hargreaves KM. Activation of Excitatory Amino Acid Receptors in Bovine Dental Pulp Evokes the Release of iCGRP. J. Dent. Res. 78:54-60, 1999.
Garry MG, Jackson DL, Geier HE, Southam M, Hargreaves KM Evaluation of the efficacy of a bioerodible bupivacaine polymer system on antinociception and inflammatory mediator release. Department of Restorative Sciences, University of Minnesota Schools of Dentistry and Medicine, Minneapolis 55455, USA. Pain 1999 Jul;82(1):49-55 mgarry@mednet.swmed.edu.
Shaefer JR, Jackson DL, Schiffman EL, Anderson QN. The diagnostic validity of magnetic resonance image effusions and pressure pain thresholds for the identification of temporomandibular arthralgia. (submitted J. Dent. Res., 2000).
Cai S, van der Ven PF, Jackson DL. Evaluations of ATP-evoked iCGRP release from dental pulp J. Dent. Res. 79:174, 2000.
